For the relief of seasonal allergy symptoms such as : Runny nose, Sneezing, Sinus pressure and headache, Sinus congestion, Nasal congestion .
Adults and children 12 years of age and older: Pump 1-3 times in each nostril .
Children under 12 years of age : consult a doctor before use .
To use pump: Shake well. Remove cap and safety clip. Hold with thumb at the bottom of bottle and place nozzle between fingers. Before using the first time,
prime pump by depressing several times.Insert nozzle into nostril and firmly depress rim sniff deeply.
Side effects : Upon initial use, you will experience a powerful sensation which lasts a few seconds . This sensation is inherent to the process that allows capsaicin to work. Temporary discomfort such as burning or stinging sensation, sneezing or an increase in nasal discharge may result .
Cautions : 1. Avoid contact with eyes. in case of accidental contact, rinse your eyes copiously with water and seek professional assistance immediately.
2. The use of this container by different persons may cause and spread contamination .
3. Stop use and consult a doctor if symptoms persist more than two weeks or worsen , or if you experience dizziness or palpitations.
4. Keep out of reach of children .
5. Consult you doctor before use if you have :
* Ever had any medical procedures on your nose or sinuses, or you are susceptible to nose bleeds .
* Allergies to any of the ingredients .
Pregnancy and Lactation : Consult your doctor before use .
Each 100ml of Allergol nasal spray contains:
Dry extracts of : capsicum annuum 375 micg, urticaria dioica 500micg . In addition to the essence of Eucalyptus spp, Rosmarinus officinalis and powder of menthol.
Capsicum annuum – Capsaicinoids, chief components capsaicin(32-38%), dihydro – capsaicin , carotinoids – alpha – carotin , capsanthin flavonoids – apiin , Luteolin -7-0- glucoside, saponins – capsicidine ,Urticaria dioica – steroids : beta – sitosterol, campesterol , stigmasterol, polysaccharides : glucans , glucogalacturonans
Hydroxycumarines : Scopoletin , lectins : isolectin mixture ,Rosmarius officinalis: rosmarinic acid, carnosolic acid, hesperidin, oleanolic acid , ursolic acid ,
Eucalyptus -volatile oil : 1,8 – cineol, alpha – pinenes, camphene, geraniol , flavonoids – rutin, hyperoside
Allergic rhinitis represents a global health problem . Non – specific nasal hyperresponsiveness is an important feature of allergic and non – allergic rhinitis. This phenomenon is believed to result from the effect of allergic inflammation on the sensory nerves that supply the upper airway mucosa. A pharmacologic agent that has proved efficacy, is capsaicin . Intranasal capsaicin specifically stimulates afferent nerves. As a result, it can trigger central and axonal reflexes, the latter being putatively mediated by the release of neuropeptides. Capsaicin as a blocking agent of neuropeptides, blocks the axon reflex and may exert a curative effect on allergic rhinitis (1,2). Capsaicin also demonstrates antimicrobial activity in vitro (3) . The extract of stinging Nettle leaves and its main phenolic component, caffeic malic acid have been shown to inhibit the biosynthesis of arachidonic acid metabolites in vitro and there is a strong concentration dependent inhibition of cyclooxygenase induced reactions(3).Also, a phenolic acid isolate form the extract inhibited the synthesis of leukotriene B4 . This study demonstrates that the antiphlogistic properties of Urtica dioica are due to enzymatic actions on more than one pathway(4) . In 1990 a double – blind, placebo – controlled study was done to assess the use of stinging nettle leaf in allergic rhinitis (5). The results showed that the plant is helpful in the treatment of allergic rhinitis and its inhibitory effects on prostaglandins and leukotriene synthesis explain its antiallergic activity. Many studies have shown that rosmarinic acid can be an effective intervention for mild seasonal allergic rhinoconjunctivitis (SAR)- at least partly - through the inhibition of PMNL infiltration into the nostrils (6), and a significant reduction in the numbers of neutrophils and eosinophils in nasal lavage fluid (p<0.05 v5. placebo) was also observed . L – menthol significantly suppressed the production of each of the three inflammation mediators by monocytes in vitro . Leukotrien B4 ,prostaglandins and interleukins. Therefore, therapeutic efficacy of L – menthol in the treatment of allergic rhinitis was quite obvious (7). Eucalyptus applied locally relieves nasal congestion due to the common cold . Eucalyptus and its oil have shown antibacterial activities and are used for respiratory conditions including cough, nasal stuffiness, bronchitis and asthma .