Oral, Ear, Nose and Throat Diseases

Salvizan Gel

Salvizan 3d

Indications

As an antiphlogistic for inflammation of the gum and the mucous membranes of the mouth and throat , for gingivitis and stomatitis.

Dosage

Apply about 1 cm gel on the mouth mucosa and rub with finger tip 3 times a day.
Packaging : Tube of 15 g gel .

Contraindication

It is not recommended during pregnancy. In lactation period it should be used with caution.
Side effects :
Extra use of Salvizan gel may lead to dryness of the mouth. In sensitive individuals to plant material may induce sensitization.

Other therapeutic effects :
Salvizan gel can be used in aftus , stomatitis, gingivitis, glossitis and laringitis.

Composition

Each 15g of Salvizan gel contains 28% hydroalcoholic extract of salvia officinalis ( sage leave ) ( 1: 2 ratio ).

Constituents

Sage leave contains 3-8% condensed catechin–type tannins (Salviatannin ) : phenolic acids ( Rosemarinic , caffeic , chlorogenic , ferulic and gallic acids ) ; 1-3% flavonoids ( apigenin and luteolin derivatives ) : volatile oil (monoterpenoids , α – thujone
- thujone , camphor , cineole , humulene , α pinene camphene , limonene , bornyl acetate and carnosol.

Drug Form

Gel

Pharmacological actions

The surfaces at the back of the mouth and pharynx are the first point of contact for ingested or inhaled pathogens and irritants ; the dense masses of lymphatic tissue in the region confirm their important role in defence. Salvizan gel appears to mobilize activity in the surrounding lymphatic tissues , through its active constituents (1).

It has been experimentally proven that sage products is astringent , antiseptic and disinfectant ( against inflammation ). It is antibacterial ( 1,2,3 ) fungistatic , virustatic stimulating and can be used in mouth rinses and gargles for inflamed tissue of the oral cavity and throat ( 1,2 ).

It`s volatile oil has antimicrobial activity attributed to its thujone content ( 3,4,5 ).
In Germany , sage is licensed as a standard medicinal tea which is applied topically as a rinse or gargle for inflammation of mouth and throat (6).

The combination effects of antiphlogestic , antiseptic fungistatic explain the mechanism of action of this drug.

Reference

11.Jalsenjak V, Pelingak , S,Knstrak , D . 1987 Microcapseles of sage oil : Essential oils content and antimicrobial activity . Pharmazie 42 ( 6) : 419 – 420 .
2. Todorovs . 1994 Experimental Pharmacological study on saliva . Acta Phsiol Pharmacol Bulg 13-20 .
3. Newall , C. A., L.A . Anderson . J. D. Philipson . 1996 Herbal Medicines ; Guide for Health Care Professionals London ; The Pharmaceutical press.
4. Jalsenjak, V. S. Pelinjak , D. Kustrak , 1987. Microcapsules of sage oil : Essential oils content and antimicrobial activity , Pharmazie 42 (6) : 419 – 420.
5. Karnick, C.R. 1994. Pharmacopoeial standards of Herbal plants ; Delhi ; Sri satguru Publications. Vol 1 : 324 – 325 , Vol 2 : 114 .
6. Wichtl, M. and N.G. Bisser. 1994 Herbal Drugs and Phytopharmaceuticals ; Stuttgart : Medpharm Scientific Publishers.