Oral, Ear, Nose and Throat Diseases

Melissan Gel 5 mg

Melissan 2 3d

Indications

Viral infections of the skin (cold sores and zoster ) , antibacterial (Acne).

Dosage

Apply locally 3 times a day on the infected area .

Contraindication

Side effects :There has been no report of side effects of Melissan gel so far.
Contraindications : None known
Pregnancy and Lactation : No restriction known in Pregnancy and Lactation .

Composition

Melissa officinalis dried extract (1% ) in gel base standardized on the basis of 0.23% tannic
acid.

Drug Form

Herbal Gel 5g

Active ingredients

 Melissa officinalis contains the flavonoids quercetin , rhamnocitrin , and the 7- glucosides of apigenin , kaempferol , quercetin and luteolin , phenolic acid and tannins ; chiefly rosmarinic acid ( up to 4% ) , and glycosidically bound caffeic and chlorogenic acids; triterpenes , volatile oil( citronellal, geranial, neral and sesquiterpenes ( - caryophyllene ).

Pharmacological actions

S
ome modern studies have investigated the external use of Melissa extract to treat cutaneous Herpes simplex lesions (1). The approved modern therapeutic applications of Melissa officinalis are supportable based on its long history of use in well established systems of traditional medicine , on phytochemical investigations and on its documented pharmacological actions reported in vitro studies and in in vivo experiments in animals (2). A study on Melissa officinalis ( lemon balm) found that the plant extract possessed antiviral activity against a number of viruses including HSV ( Herpes Simplex virus ) (3). The extract appeared to inactivate viruses directly. Subsequent studies demonstrated that the antiviral activity of Melissa was due to tannins (4) but also to nontannin polyphenolic fraction. Phenolcarboxylic acids (e.g. caffeic and rosmarinic acid ) and their glycosides ( e.g. chlorogenic acid ) in Melissa , together with polymers formed from oxidation of these compounds were later identified (1). Although, such components are common in many plants , especially the Labiatae family, they are present at relatively high concentrations in Melissa. Their polymerization is responsible for the blackening of Melissa leaves which occurs on drying. These compounds were suspected to be nontannin antiviral agents in Melissa. Subsequent research found the Melissa extracts could inhibit protein biosynthesis in vitro and caffeic acid and probably its polymerization products were found to be active, but chlorogenic acid was not active. An unidentified glycoside was also responsible for significant inhibition of protein synthesis (1).
Despite the chemical and pharmacological uncertainty , clinical trials with Melissa for the topical treatment of recurrent HSV type 1 infections have yielded
conclusive results. One study found an improved
healing rate for 75% of patients with the time between outbreaks prolonged in 50% of cases (5).
Compared to conventional treatments average healing time of lesions was halved to about 5 days and the interval between outbreaks was approximately doubled (6). In another multicentre study on 115 patients , treatment of lesions was commenced between 24 and 72 hours from their outbreak (3). It was found that lesions in 87% of patients were completely healed within 6 days of treatment. The time between outbreaks was prolonged for 69% of patients and the average time was 2.3 months with Melissa treatment compared to 1.3 months for conventional treatments such as idoxuridine and tromantiadine. Minor side effects were observed in only 3% of patients (6).Melissa officinalis has antibacterial actions, Melissa preparations have been used in the treatment of acne. It also inhibits the inflammatory process of acne and has been used effectively in the treatment of acne (7,8).

Reference

1. Escop, 1997 Mellissa folium . Monographs on the medicinal uses of plant Drugs. Exter , U.K:
European scientific cooperative on phytotherapy.
2. Schultz V. Hansel R.Tyler U. Rational phytotherapy. A physician's guide to herbal medicine, New York, NY : Springer – verlag ; 1998.
3. Vogt.H.J. et al. Melissenextrakt bei Herpes simplex. Der Allgemeinarzt 13: 832 – 841 , 1991.
4. Wobling RH, Leonhardt K. Local therapy of Herpes
simplex with dried extract from Mellissa officinalis. Phytomedicine ,1994;1: 25 – 31.
5. Nakashima, H. , Murakami, T. , Yamamoto. N. et
al. (1992). Inhibition of HIV Replication by tannins and related compounds. Antiviral Res. 18. 91-103.
6. Wobling, R.H. and R. Milbradt. Klinik und Therapie des Herpes simplex. Vorstellung eines neuen phytotherapeutischen Wirkstoffes. Therapiewoche , 34:1193-1200, 1984.
7. Tgashira M, Ohtake Y. New Antioxidative 1.3 Benzo dioxole from Melissa officinalis. Planta Med. 1988, 64 : 555 – 558.
8. Bourne Kz., Bourne N., Shirloy F. Stamberry , L .
R. Plants products as topical microbicide candidate. Antiviral Research 42 ( 1999) 219 – 226 .