Cardiovascular

Vasogol Tablet

Vasogol 3d

Indications

 Mild hypertension, Diuretic, in combination with other antihypertensive drugs .

Dosage

 Take daily 1 – 2 tablets with meal .

Contraindication

Side effects : Bronchial Asthma, Allergic rhinitis and gastrointestinal problems, has been reported.

Contraindications : The administration of the drug can trigger colic among gallstone sufferers, so, in these patients, consumption is contraindicated..

Warning : Patients on Anticoagulant or Antidiabetic drugs must use this drug with caution

Pregnancy and Lactation: The safety of this drug – during pregnancy and lactation  has not yet been established.

Composition

 Each vasogol tablet contains: 580mg dry extract of Olive Leaf. 

Constituents

Fatty acids: Oleic acid, Palmitic acid , Linoleic acid .  Monoterpenes: Oleoropine .Triterpenes : Oleanolic acid . Flavonoids : Luteolin -7-0-glucoside, Apigenin -7- 0- glucoside .  Chalcones : olivin

Stands on : oleoropine 13% equivalent to 75mg active constituent .

Drug Form

 Coated tablet

Stands On

 Stands on : oleoropine 13% equivalent to 75mg active constituent .

Pharmacological actions

Several phenolic compounds are found the olive leaf and bud such as oleoropine (phenolic glucoside) and flavonoids. oleoropine is a natural antioxidant then the more oleoropine in a particular product, the more effective it is in lively to be and is responsible for its therapeutic effects,  oleoropine in the body is metabolized to linoleic acid. Linoleic acid possess broad spectrum antibacterial activities (1,2).  The olive leaf extract inhibits some viruses in vitro including rhinovirus, myxoviruses, Herpes simplex type I, Herpes simplex type II, and many strains of influenza and parainfluenza viruses(2,3) . It has been reported that the olive leaf extract has vasodilatory action (4) . As an antioxidant, oleoropine has been reported to decrease the oxidation of LDL cholesterol and reduce the development of atherosclerosis. Olive leaf extract has also been reported to inhibit the production of  thromboxane A2 and platelet aggregation (5) . Oleoropine was also shown to enhance nitric oxide production (6) . After bio assay directed fractionation, 3,4 – dihydroxy – phenyl – ethanol, a degradation product of oleoropine was shown to have such potential (10). Other B- glucosidase produced metabolites of oleoropine and oleacin have been shown to inhibit the angiotensin converting enzyme (7,10). A certain role in the pathogenesis of hypertension is also ascribed to oxidative stress(8). Based on the ability of oleoropine and polyphenolic compounds to scavenge free radicals and reactive oxygen species extracts from olive leaves have high antioxidative activity . In a clinical trial on hypertensive patients, olive leaf extract reduced the blood pressure significantly (9,11) .

Reference

1.Pereira, A.P. et al. Phenolic compounds and antimicrobial activity of olive colea europaea L. Cv. Cobrancosa)Leaves. Molecules, 2007. 12:1153-1162.

2.Bisignano, G. et al. On the in-vitro antimicrobial activity of oleoropine and hydroxytyrosol. J. pharm pharmacol., 1999. 51(8): 971-4.

3.Yaseen Khan, Md. et al. Olea europaea: A phyto- pharmacological review. Pharmacognosy Reviews, 2007. 1(1): 114-118.

4.Zarzuelo, A et al. Vasodilator effect of olive leaf. planta med., 1991. 57(5) 417-9.

5.Petroni, A. et al. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb Res., 1995. 78(2):151-60.

6.Visioli, F. et al. Oleoropine the bitter principle of olives, enhanaces nitric-oxide production by mouse macrophages.Life Sci., 1998. 62(6): 541– 6.

7.Hansen, K. et al. Oleoropine of an angio rennin conversing enzyme (ACE) inhibitor from olea. European phytomedicine, 1996. 2: 314-25.

8.De Champlairn, J. et al. oxidative stress in hypertension. Clin. Exp. Hypertens, 2004. 26: 593-601.

9.Cherif, S. et al. A clinical trial of a titrated olea extract in the treatment of essential arterial hypertension. J. Pharm. Belo.,1996. 51:69-71.

10.Perrinjaquet-Moccetti, T. et al. Food supplement extraction with an olive leaf extract reduces blood pressure in borderline hypertensive momozygotic twins.Phytotherapy Res., 2008. 22: 1239-1242.

11.PDR(3rd ed.), 2004. pp: 604-606.