Muscle

Phytoglucosamine Gel

Phytoglucosamine 3d

Indications

Osteoarthritis, facilitating joint movement, joint pain, maintaining the connective tissue in the joint.

Dosage

Apply a thin layer of gel on the affected area and rub smoothly, repeat 6 times a day.

Contraindication

Contraindications: Phytoglucosamine Gel should not be used during pregnancy, lactation and in children under 12 years of age.

Cautions: Do not use this product on damaged skin, and around the eye.

Adverse – reactions: No side effect is reported so far. In case of induced local irritation, do not continue using the product.

Composition

Each 30g of phytoglucosamine gel contains Acetyl glucosamine 3g , the dry extract of Aesculus hippocastanum 0.6g , menthol powder (Horse – chestnut) 0.003g .

Constituents

Aesculus hippocastanum (Horse – chestnut) contains a mixture of saponins collectively referred to as aescin glycosides, coumarins (Aesculetin, fraxin, scopolin ) flavonoids (flavonol , quercetin erivative), estrals .

Drug Form

Gel

Pharmacological actions

Naturally glucosamine is found in high concentration
in the joints. It has been hypothesized that glucosamine stimulates the formation of cartilage that is essential for joint repair (1). It facilitates movement of joints(2) . Glucosamine is an amino sugar. Hyaloronic acid is found in the joint cartilage and synovial fluid and is formed from pair units of glucoronic acid, as acetyl glucosamine(3). Glucosamine plays an important role in joint health and resiliency (4). In the process of aging, glucosamine content of cartilage is wasted progressively. This, in turn, leads to thinning of cartilage resulting in the onset and progression of osteoarthritis .
Antiinflammatory activities and anti edema effects in rats has been documented for both a fruit extract and the saponin fractions of horse chestnut. Aescin may affect the initial phase of inflammation by reducing the number and / or diameter of capillary pores effectively sealing the capillaries. As found in different animal tests and preclinical investigations, the principal ingredient of Horse chestnut seed extract, has an anti – exudative vascular tightening effect and reduces vascular permeability which prevents the formation of edema in tissue(5). Significant improvement in the symptoms of chronic venous insufficiency was demonstrated in diverse, randomized, double – blind and cross – over studies (6). Inhibition of cyclooxygenase activity of Japanese horse chestnut seed extract has been demonstrated (7). The combination of glucosamine, menthol and the extract of Aesculus hippocastanum work synergistically to facilitate joint movement and relieve joint pain and inflammation.

Reference

1.Dahmer S. Schiller R.M. Am. Complementary and
Atternative Medicine Glucosamine Fam physician 2008; 78(4): 471 – 476 .

2.Leffler CT, Philippi AF. et al. Glugosamine, chondritin , and manganese ascorbate for degenerative joint disease of the knee or low back : a randomized , double blind, placebo – controlled pilot study. Mil Med, 1999; 44(1) : 75 – 80 .

3.Mc Alindon TE et al. Glucosamine and chondroitin for treatment of osteoarthritis JAMA 2000, Mar 15
, 283(11) : 1469 – 75 .

4.Cohen M et al. A randomized double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate and camphor for osteoarthritis of the knee . I Rheumatol 2003, 30(3) : 523 – 8 .

5.R for Herbal Medicines 3rd Edition 2004 pp.445 – 446 .

6.Calabrese c, et al. Report of the results of a double blind , randomized , single dose trial of a tropical 2% escon gel versus placebo in the acute treatment of experimentally – induced hematoma volunteers. planta Med 59 – 394 – 397;1993.

7.Guil laume M, padioleau F. veinotonic effect, vascular protection anti-inflammatory and free radical scavenging properties of horse chestnut extract. Arzneimittle forschung 1997.44(1)25– 35 .