الامراض النسائیة والتولید

Mamogol Cream

Mamogol 3d

موشرات

Cracked nursing nipples, Softening salve for sore

 

الجرعة و کيفية الإستعمال

 Apply Mamogol cream 2 – 3 times a day on the affected area of the skin

موارد الإستعمال و تحذیر

Side effects : Not reported so far

Contraindications : In sensitive individuals to plant material Mamogol should be used with cautions .

 

منتجات عنصر

Each 100 g of Mamogol contains: Concentrated extracts of : 10 g
Calendula officinalis L. 10 g Althea officinalis L 

المکونات النشطة

Calendula officinalis : Flavonol, glycosides
isoquercitrin, narcissin, Neohyperoside and rutin, terpenoids - amyrin, Lupeol, pentacyclic alcohols such as faradiol
Althea officinalis : Polysaccharides particularly galacturonic rhamnans, arabinogalactans, glucans , pectins 

شکل الدواء

Cream

الإجرات الدوائیة

Calendula promotes the formation of granulation tissue, an important step in re- epithelialization and healing of wounds (1). It is thought to increase glycoprotein, nucleo- protein , and collagen metabolism at the crack nipples or wound sites (2). An aqueous extract of calendula was shown to induce new blood vessel formation in vitro, suggesting this as a mechanism of action in promoting granulation (3). In one study, surgically induced skin wounds in rats were treated with a 5% calendula ointment in combination with allantoin . Histological studies of the damaged tissue were performed at 8 hours, 24 hours and 48 hours after the infliction of the wounds. The drug combination was found to markedly stimulate physiological regeneration and epithelialization. This effect was attributed to more extensive metabolism of glycoproteins, nucleoproteins and collagen protein during the regenerative period in the tissues (4) . Aqueous extracts from the roots of Althea officinalis L(AE) are widely used for treatment of irritated mucosa. The clinical proven effects are related to the presence of bioadhesive and mucilaginous polysaccharides from the rhamnogalacturonan type, Leading to the physical formation of mucin – Like on top of the irritated tissues . AE (1,10 micro g/ml) had stimulating effect on cell viability and proliferation of epithelial KB cells(5). The combination of calendula and Althea officinalis affect the irritated nipple tissue and promote its healing. Studies conducted in vitro in animal models have elicited many potentially useful effects related to compounds present in calendula officinalis. The flowers are antimicrobial due to terpene alkaloids lactone and flavones contained in essential oil
The unesterified faradiol was found to be the most active anti- inflammatory compound, equal to indomethacin(6)
Althea officinalis extract alleviates local irritation, Stimulates phagocytosis, and functions as an anti- inflammatory and anti complementary agent.
The presence of polysaccharides in Calendula and Althea officinalis both promote tissue regeneration and healing of cracked nursing nipples  

مصدر

1. Bisset, NG Calendula floss– marigold . In : Herbal Drugs and phytopharmaceuticals ; a Handbook for
practice on a scientific Basis. Medpharm scientific
Publishers, Stutlgart and CRC press, Boca Raton, Fl, USA, 1994 .

2. Anon, Calendula Monograph in Olin BR(ed) the Lawrence Review of Natrual Products. Facts and Comparisons, St Louis, Mo, January 1995.

3. Patrick KFM et al . Induction of Vascularisation by an aqueous extract of the flowers of Calendula officinalis L. in Phytomedicine, 3(1): 11 – 18, 1996 .

4. Kloucek – Popova E et al. Influence of the Physiological regeneration and epithelization using fractions isolated from Calendula officinalis . in : Acta physiol pharmacol Bulg; 8(4): 63 – 67, 1982 .

5. Deters A et al. Aqueous extracts and Polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro. J. Ethnopharmacol 127(1) : 62 – 9 . 2010 .

6. Della Loggia R et al. the role of Triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers . In : PM 60(6): 516 – 520 , 1994 .